Monoclonal Antibodies Products
Monoclonal Antibodies are used in diagnostics which specifically recognize certain molecules. The widespread use of monoclonal antibodies is based on inherent characteristics like safety, broad range of potential targets, high selectivity, high affinity as well as ease of preparation. Further, they are also used for research and diagnostic purposes, in particular for selection of compounds. The range offered under this category includes Herclon / Trastuzumab Injection, Rituximab Injection, Cetuximab Injection, Bevacizumab Injection, Natalizumab Injection and Infliximab Injection.
Herclon / Trastuzumab Injection
Herclon / Trastuzumab Injection has active ingredient as Trastuzumab (Herceptin) which is a monoclonal antibody which interferes with HER2/neu receptor. The main use of the injection is to treat certain breast cancers where Trastuzumab functioning as an antibody binds selectively to HER2 protein and prevents epidermal growth factor from binding, thus inhibiting effects of HER2 over-expression. Biding to HER2 proteins of cancerous cells, HER2 protein no longer cause cells in breast to uncontrollably reproduce, thus improving prognosis of women with this type of cancer
Rituximab Injection comprises a genetically engineered chimeric murine/human monoclonal IgG1 kappa antibody that is directed against CD20 antigen. With an approximate molecular weight of 145 kD, Rituximab features binding affinity for CD20 antigen of approximately 8.0 nM. Further, Rituxan is formulated in polysorbate 80 (0.7 mg/mL), sodium chloride (9 mg/mL) , sodium citrate dihydrate (7.35 mg/mL) and water for injection. With a pH of 6.5, Rituximab injection finds usage alone or in combination with other medicines for effectively treating non-Hodgkin's lymphoma (NHL) which is a type of cancer where it helps the immune system by destroying cancer cells. Further, in combination with fludarabine and cyclophosphamide, Rituximab is used for treating chronic lymphocytic leukemia (CLL) cancer and when combined with methotrexate, it helps in treating symptoms of rheumatoid arthritis
Cetuximab Injection finds usage in treatment plan with or without radiation therapy for treating certain type of cancer of head and neck. Further, Cetuximab also finds usage alone or in combination with another medication for treating cancer affecting colon (large intestine) or rectum which has spread to other body parts. Cetuximab also has shown results of slowing growth of tumors in people having cancer of colon or rectum. From the class of medication called “monoclonal antibodies,” it works by slowing/stopping growth of cancer cells.
Bevacizumab Injection is used in chemotherapy for treating cancer of large intestine or rectum which has gained access to other parts of the body. Further, Bevacizumab also finds its use in chemotherapy for treating certain types of lung cancer, glioblastoma (a type of cancerous brain tumor) as well as in combination with other medication in treating renal cell cancer which is a type of cancer which starts from kidney and has spread to other body parts. From the class of medication “antiangiogenic agents” it works by stopping formation of blood vessels which brings oxygen as well as nutrients to tumors and thus slowing growth and spread of tumors.
Natalizumab Injection is applicable in slowing the process of worsening of disability in people that are facing relapsing forms of multiple sclerosis where nerves do not function properly. Due to which people experience conditions like loss of muscle coordination, problems with vision & speech, weakness, numbness and bladder control. The medicine works by stopping certain cells of immune system from reaching brain as well as spinal cord/digestive tract that cause damage. Other than this, Natalizumab is also used for treating and preventing arising of symptoms in people having Crohn's disease where body attacks lining of digestive tract which cause diarrhea, pain, weight loss and fever. Further, Natalizumab is also used by people on whom other medications have not proven effective.
Infliximab Injection finds usage in relieving symptoms of certain autoimmune disorders where immune system attacks healthy parts of body which causes conditions like pain, swelling and damage. From the medication class ‘tumor necrosis factor-alpha (TNF-alpha)’ inhibitors, it works by blocking action of TNF-alpha, a substance present in body that causes inflammation. This includes rheumatoid arthritis (condition where body attacks its own joints that cause pain, swelling and loss of function), Crohn's disease (where body attacks lining of digestive tract that causes pain, diarrhea, weight loss and fever) and ulcerative colitis (condition that results in swelling & sores in lining of large intestine) that occurs in adults and children of 6 years of age or older. Other than this, the injection is also used for treating cases of ankylosing spondylitis, psoriasis and psoriatic arthritis